Tainted Isaac can be a viable choice for a character, as the changed item pedestals benefit all players, not just Tainted Isaac.Tainted Magdalene synergizes with Tainted Bethany as due to Tainted Maggy's generation of heart pickups, Tainted Bethany can quickly accumulate Blood Charges.Similarly, effects that trigger on damage, such as It Hurts trigger on players who take damage, regardless of who took damage.On kill effects such as Infestation 2, Lusty Blood, or Tainted Keeper's coin drops will trigger for the player holding it regardless of which player killed the enemy.Keeper/ Tainted Keeper will not replace heart drops with flies when paired with other characters that use hearts.Tainted Cain can also work, since his Bag of Crafting entirely bypasses the reroll mechanic.
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